Optimal Sampling Times for Therapeutic Drug Monitoring
نویسندگان
چکیده
منابع مشابه
Assessment of optimal sampling times for estimation of AUC in Therapeutic Drug Monitoring by Monte Carlo simulations
The aim of the procedure is to determine the optimal sampling times for the assessment of AUC after administration of a drug, either as a single dose or during a regular dosing schedule. For a single dose, AUC is defined as the total area under the plasma concentration time profile from time zero to infinity; for a regular dosing interval at steady state, AUC is defined as the area under the pl...
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Rifampin, together with isoniazid, has been the backbone of the current first-line treatment of tuberculosis (TB). The ratio of the area under the concentration-time curve from 0 to 24 h (AUC0-24) to the MIC is the best predictive pharmacokinetic-pharmacodynamic parameter for determinations of efficacy. The objective of this study was to develop an optimal sampling procedure based on population...
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Immunosuppressants require therapeutic drug monitoring because of their narrow therapeutic index and significant inter-individual variability in blood concentrations. This variability can be because of factors like drug-nutrient interactions, drug-disease interactions, renal-insufficiency, inflammation and infection, gender, age, polymorphism and liver mass. Drug monitoring is widely practiced ...
متن کاملTherapeutic drug monitoring
(Suggestions are based on Level III and IV evidence) • In both adults and children, C2 monitoring of CSA is superior to C0 as a predictor of AUC 0–4 and AUC 0–12. The C3 level is marginally superior to C2 for AUC 0–12. • Targeting AUC 0–4 levels for CSA of greater than 4400 ng/mL or C2 levels of greater than 1.5 by the end of the first week post transplant is associated with less acute rejectio...
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ژورنال
عنوان ژورنال: Advances in Pharmacoepidemiology & Drug Safety
سال: 2012
ISSN: 2167-1052
DOI: 10.4172/2167-1052.s1-004